Paralegal Janet Gregory takes on a pro bono case to help an African-American husband and father who she believes has been wrongly accused of raping a girl in his neighborhood. Her 22-year battle with the justice system will eventually bring him the freedom he deserves and bond the two of them in a life-long friendship.

Over the last century, thousands of people have gone missing. Suddenly, 4400 fo them are returned all at once in a blinding explosion. Unclear about what this even means, the government invesitages the 4400 to piece together where they've been. But then slowly the 4400 begin to manifest strange powers, and it becomes clear that they are going to change the human race... forever!